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P = 1.00), with no intergroup heterogeneity ( P = 0.13) (Additional file 1: Fig

Examples of PPIs include omeprazole (Prilosec) and esomeprazole (Nexium)

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Even the FDA acknowledged that "patients and prescribers may still see intermittent and limited localized supply disruptions as the products move through the supply chain from the manufacturer and distributors to local pharmacies." The American Society of Health-System Pharmacists' shortage list continues to show both semaglutide and tirzepatide injection in shortage

A meta-analysis of 18 clinical trials involving more than 10,000 patients with lower limb atherosclerosis has demonstrated that lipid-lowering therapy decreases the risk of cardiovascular events by nearly 20% and reduces all-cause mortality by 14% [314]