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However, they must include some of the most commonly prescribed drug categories and classes, and most drugs in certain protected classes

Mutations in the genes encoding these proteins, as well as their abnormal expression, are associated with the pathogenesis of several diseases, including type 2 diabetes, insulin resistance, cancer, and neurodegenerative disorders

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We refer readers to the CY 2008 OPPS/ASC final rule with comment period (72 FR 66687) in which we discuss our rationale for applying these rounding principles

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