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In addition, most prior nanozymes or ROS-scavenging biomaterials in pulmonary and other inflammatory diseases emphasized broad antioxidant and anti-inflammatory effects without clearly linking their activity to upstream signaling pathways in COPD [24]

The clinical importance is debated

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Additional studies in other models, including evaluations of administration and toxicity, will be needed to determine the broader applicability of xCT inhibition in this context

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