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Interestingly, the plasma concentration achieved with once-weekly exenatide ER is comparable to that of a single injection of immediate-release exenatide (Byetta) [60, 61]

It is not FDA-approved for weight loss and is typically sold outside standard prescription channels as a compounded or research product

Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes

Established supplements like berberine have decades of research

Meanwhile, Semaglutide GLP-1 (Ozempic, Wegovy) has shown promising results in terms of weight loss, despite its primary use for treating type 2 diabetes

For example, Wegovy prescribing information states that it is used with a reduced-calorie diet and increased physical activity to help certain adults and adolescents reduce excess body weight and maintain long-term weight reduction