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Neuroprotection: Preclinical research has explored possible protective effects in age-related neurological studies

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These higher research doses established safety margins while demonstrating therapeutic efficacy

Amide reduction occurs by nucleophilic addition of hydride ion to the amide carbonyl group, followed by expulsion of the oxygen atom as an aluminate anion leaving group to give an iminium ion intermediate

The Yellow Card scheme: guidance for healthcare professionals, patients and the public