How Genetic Predispositions Add Clinical Context Emerging evidence suggests genetic variation in GLP-1 and related metabolic pathways influences how individuals respond to treatment
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GLP-1s can also cause gastrointestinal issues such as nausea and vomiting, which may cause some people to discontinue use due to side effects before achieving their weight-loss goals
Metformin is a lower-cost option compared to GLP-1 medications, suitable for those seeking modest weight loss or who dont qualify for or prefer to avoid GLP-1 drugs and needles
Regarding direct anti-tumor effects, studies have demonstrated that GLP-1RAs exhibit multiple functions, including inhibiting tumor cell proliferation, inducing apoptosis, and preventing tumor cell migration and invasion
Flint A, Raben A, Rehfeld JF, Holst JJ, Astrup A