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The lack of universal dosing protocols, as well as abuse outside of medical supervision, work to heighten these issues of safety

FASEB J 19:15046, PMID: 15972297 Kanno T, Nishizaki T (2001) Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c

34 This fact limits the therapeutic use of glutathione GSH by the oral route

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