The peptides sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) was first characterized by research groups investigating cytoprotective properties of gastric juice-derived compounds
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doi: 10.1016/j.jada.2010.03.018 131
However, observed barrier defects and associated diarrhea even in these mice did not result in changes in claudin-1, -2, -3, and -4 expression and cellular distributions, but rather correlated with the rearrangement of cellular distribution of occludin, and to some extent with JAM proteins
[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Balla G., Jacob H