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Not every patient is an appropriate candidate, and a responsible clinician will always screen before recommending treatment

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The genes involved in autism are variable and diverse, but mutations in genes related to the mTOR (mammalian target of rapamycin) pathway are most widely associated with autism (1)

The rationale for why hypertonic saline could augment loop diuretics is as follows: Hypertonic saline could improve chloride levels, thereby reversing the effects of hypochloremia on sodium retention (explored above)

Useful soft tissue endpoints include: muscle fibre organisation vascular response inflammatory marker panels collagen deposition fibroblast activity oxidative stress markers histology scoring cell migration These research areas overlap with tendon and ligament studies but focus more broadly on tissue integrity and repair-associated signalling

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