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Relatively, there are still plentiful studies suggesting that soluble UA is a risk factor for bone loss under the premise of hyperuricemia, while periodontal inflammation involves alveolar bone loss

El-Sehrawy et al., 2025

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Madaio was corresponding author of a study this summer also in Kidney International that showed that using the same antibody, this time to deliver the anti-inflammatory protein kinase C-alpha inhibitor directly to the kidney, enabled the organs recovery in a similar model of nephritis

Patients were followed for 108 weeks

Editors Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction