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[,] AIMS AND OBJECTIVES There being no study comparing the efficacy of oral tranexamic acid versus glutathione in the management of melasma, we undertook the present study comparing the efficacy of topical modified Kligman regimen with oral tranexamic acid versus oral glutathione in the management of melasma

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Thus, the stepwise recruitment of distinct coactivators by VDR during keratinocyte differentiationfrom early proliferative regulation to terminal differentiationconstitutes a dynamic transcriptional control mechanism essential for maintaining epidermal structural integrity and functional homeostasis

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This enzymatic stimulation appears tissue-specific, as Epithalon selectively protected aged human pinealocytes from degenerative changes while promoting functional restoration of the gland's secretory capacity