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Studies suggest that AOD9604 does not bind the growth hormone receptor and does not activate the JAK2/STAT5 pathway, which accounts for the absence of growth-promoting or IGF-1-elevating effects observed in animal studies

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One dose every 4 weeks for 12 weeks, total of 3 doses, 14.5% #weightloss We never know what we don't know @Amgen Just some of the fascinating insights that rocked the GLP-1 incretin world this week-a glimpse of top line data for AMG-133 the GIPR Antagonist-GLP1R Agonist antibody