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Istotn cech jest zaleno insulinotropizmu od glukozy: aktywacja GLP-1R nie wywouje nadmiernej insulinemi przy normoglikemii, co tumaczy niski inherentny potencja hipoglikemii tej klasy lekw (GLP-1 receptor agonists: an updated review of head-to-head clinical studies PMC) (Glucagon-Like Peptide-1 Receptor Agonists StatPearls NCBI Bookshelf)

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