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Sinomenine protects bone from destruction to ameliorate arthritis via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop

doi: 10.1002/mc.22325 144 KawabataAYanaiharaNNagataCSaitoMNoguchiDTakenakaMet al

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However, one limitation is that while we are utilizing STEP 1 eligibility criteria to identify the eligible NHANES participants, there may be differences between our participants and the STEP 1 clinical trial participants, and therefore the weight loss and cardiovascular risk factor changes observed in STEP 1 may not be entirely translatable to our NHANES sample