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The role of oxidative stress in Friedreichs ataxia

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Redox regulation at the level of the secondary sulfur metabolic pathway While SOT represent the largest protein family among sulfate-assimilating proteins, their biochemical and functional characterization still lags behind and this is also true for the associated regulation mechanisms

The produced H 2 O 2 enters the cells via aquaporin, the protein channel generally associated with water transport, and triggers the activation of the NRF2 factor [160]

Phytocompounds like 5-(7a-Isopropenyl-4,5-dimethyl-octahydroinden-4-yl)-3-methyl-pent-2-en-1-ol showed the highest binding affinity (-10.061 Kcal/Mol) with ES1 (pdb id-1A52) and formed two H-bonds at the residues Glutamic acid (GLU) 353 and Arginine (ARG) 394