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These promising results led to the development of the first dual agonists, with tirzepatide, a GIP and GLP-1 receptor agonist, being the most prominent one

GLP-1 was shown to manage blood sugar levels by improving insulin function, lowering glucagon levels, and delaying gastric emptying

Weve also seen data that semaglutide has been shown to have anti-inflammatory and cardiovascular benefits, which can further protect the kidneys from damage. If the heart pumps better, Whyte added, the kidney is going to function better. The role of GLP-1 medications for treating obesity is just one of several surprising findings uncovered since their introduction to the market

Monitoring report: GLP-1 RA prescribing trends - September 2024 Data

But a 4-8 week drug holiday is much shorter than the 28-52 week discontinuation periods in those studies

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