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In December 2014, they published a paper in Nature Medicine, showing that the triple agonists weight loss effects in mice exceeded those of the dual agonists

Theres also the issue of electrolyte imbalance

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SURMOUNT-2, in participants with type 2 diabetes, showed 12.8% and 14.7% weight loss at 10mg and 15mg respectively

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The main differences across comparison categories are: Mechanism of Action: advantage goes to Bioglutide