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Advocates propose that boosting NAD+ could increase energy levels, enhance mitochondrial function, and improve fatigue or cognitive clarity in some individuals

many formulations add B12

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However, most patients do not experience serious symptoms, with one study showing only 4% of patients experienced intense diarrhea

In practice, and in view of clonazepams adverseeffect profile, a short, timelimited course of the combination during the initial 4 weeks may be considered when rapid quality of life improvement is prioritized, whereas liquid NAC monotherapy is likely sufficient over an 8week horizon for patients for whom minimizing benzodiazepine exposure is preferred