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Altered Metabolism of Bile Acids Correlates With Clinical Parameters and the Gut Microbiota in Patients With Diarrhea-Predominant Irritable Bowel Syndrome

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Response to stress Activation of CRF signaling CRF expression is upregulated in the hypothalamus and the peptide released into the median eminence under conditions of stress leading to pituitary ACTH and subsequently adrenal glucocorticoid hormone release (cortisol in humans and corticosterone in rodents) (Turnbull and Rivier, 1997