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These findings lend support to the hypothesis that high levels of oxidative stress may contribute to the pathophysiology of depressionthough its effects may be anatomically selective

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Splenocytes from -MYC mice and wild-type littermates were isolated as previously described [53] and stained with APC-conjugated rat anti-mouse CD45R/B220 (ref 561880) and PE-conjugated rat anti-mouse CD43 (ref 561857) antibodies, both from BD Biosciences, before flow cytometry analysis with a FACS Canto II flow cytometer (BD Biosciences) employing Kaluza software (Beckman Coulter)

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In conclusion, we demonstrated in the first half of Figure 1 that pre-treatment with GSSSG or LASSS effectively prevents nitration of HGF-Y198, Y250, thereby preserving the ability of HGF to activate myogenic stem satellite cells in vitro through the c-met signaling pathway (panels b-d and panel e left column)