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Many compounds that looked effective in animals later failed human trials or revealed safety concerns

Never spray directly onto the lyophilized powder

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Food and Drug Administration (FDA) approval of oforglipron as a diabetes treatment as soon as possible. The company is already pursuing approval of orforglipron for obesity, and expects a decision from the FDA this spring

While nausea and vomiting are more common with short-acting agents, side effects such as itching or nodules at the injection site are more common with long-acting agents and usually disappear in 3 to 4 weeks