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Upon binding to its own receptor, IGF-1 signals the pituitary gland to secrete less growth hormone and, at the same time, tells the hypothalamus to secrete less GH-releasing hormone

Almost all included studies did not have respiratory diseases as a primary outcome, and these outcomes were derived from adverse event reports while not detecting changes in lung function

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4.1 Metformin Metformin has been widely used in the treatment of T2DM

The condition is caused by decreased blood supply to the optic nerve and may cause sudden, irreversible vision loss

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