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Warnings Patients who have early Leber's disease (LHON) a hereditary disease that causes optic nerve atrophy have been found to suffer severe and swift optic atrophy when treated with vitamin B12

In vitro studies using adipocyte cell lines, including 3T3-L1 cells and primary adipocyte cultures, have used this compound to examine lipolytic signalling, triglyceride hydrolysis mechanisms, fatty acid oxidation pathways, and adipokine secretion

B12 injections are indicated for patients with documented deficiency, including those with pernicious anaemia, malabsorption disorders, following gastric surgery, or with neurological symptoms suggesting B12 deficiency