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4a) are conserved

In MASLD, reduced SIRT1 activity leads to hyperacetylation and stabilization of PLIN2 and PLIN3, effectively locking lipid droplets and impairing lipophagic clearance, exacerbating triglyceride accumulation

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The American Journal of Sports Medicine, 48 (8), 1916-1928

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Glutathione safeguards these mitochondria by neutralizing reactive oxygen species (ROS) before they can damage the mitochondrias fragile structure