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GLP-1 drugs like Ozempic and Zepbound are transforming obesity treatment, yet 40-85% of patients are plagued by adverse GI eventsparticularly women

These are critical to regulate the electrophysiological activity of neuronal cells, to maintain the sodium concentration gradient at the BBB that drives sodium-dependent transport processes, and to regulate the intracellular endothelial pH [12]

For example, IL-6 blockade (Tocilizumab) could curb the deleterious systemic effects of IL-6 released upon mtDNA-TLR9 activation

It does not allow an enzyme IC 50 or a cell-culture concentration to be converted into a dose

Simopoulos AP

Physiology Biochem