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Tirzepatide has been studied in two massive clinical trial programs, SURPASS for type 2 diabetes and SURMOUNT for weight management, collectively enrolling tens of thousands of participants across multiple countries and treatment durations

They didn't change anything else, not their diet, not anything

These results agree with those from Murali et al (23)

Patients at increased risk of gastrointestinal bleedingsuch as those aged over 65 years, with a history of peptic ulcer disease, or taking corticosteroids or selective serotonin reuptake inhibitors (SSRIs)may benefit from co-prescription of a proton pump inhibitor (PPI) for gastroprotection, as recommended by NICE guidance

Frontiers in molecular neuroscience

Taking Mucinex with food can help reduce this feeling