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Users stopping retinoids frequently report rapid regression of benefits within 4-8 weeks including increased breakouts sometimes exceeding pre-treatment levels (retinoid rebound), accelerated fine line reappearance approaching or surpassing baseline, skin texture deterioration returning to pre-treatment roughness, and psychological dependency from dramatic visible decline creating pressure for continuous use despite side effect burden

G3 13:jkad147 Minges A, Ciupka D, Winkler C, Hppner A, Gohlke H, Groth G (2017) Structural intermediates and directionality of the swiveling motion of pyruvate phosphate dikinase

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181 , K37K41 (2019)