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GLP-1 therapy slows the emptying of the stomach by binding to the receptors that are in the stomach

N Engl J Med 370:794797 Monami M, Dicembrini I, Nardini C, Fiordelli I, Mannucci E (2014) Glucagon-like peptide-1 receptor agonists and pancreatitis: a meta-analysis of randomized clinical trials

Quick summary Bacteriostatic water is sterile water with a small amount of benzyl alcohol added

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After 46 weeks of treatment: 0.6 mg dose: 6.2% mean body weight reduction 2.4 mg dose: 12.5% mean body weight reduction 3.6 mg dose: 13.2% mean body weight reduction 4.8 mg dose: 14.9% mean body weight reduction (all randomized) 4.8 mg dose: 18.7% mean body weight reduction (completers only) Placebo: 2.8% mean body weight reduction Among completers at the 4.8 mg dose, 68.8% achieved at least 10% weight loss, 67% achieved at least 15%, and 40% achieved at least 20% weight loss

The savings are $1,500 to $3,000 annually, and compounded tirzepatide doesn't interact with Medicare Part D coverage phases