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If the increased demand is not met by the increased thiamine supply, a state of TD may easily follow, first in enterocytes, and after some period at the level of organism, most often manifested as Wernicke encephalopathy (145147)

Yet, riboflavin supplementation is increasingly explored in specific clinical settings, for example in case of preeclampsia 24 , anemia during pregnancy 25 , Parkinsons disease and migraine 26 , and female 27 , and postpartum depression 28 , as further discussed below

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