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Since GLP-1 is rapidly degraded by DPP-4 and both peripheral and central GLP-1 reduces food consumption, it has been proposed that there may be a signaling link between peripheral GLP-1R activation and central GLP-1 release from the nucleus of the solitary tract (Trapp and Hisadome, 2011)

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These cascades promote protein synthesis via mTOR activation, inhibit protein degradation through FOXO suppression, and stimulate satellite cell proliferation and differentiation

4.4 Risk of decreased pelvic floor function in PCOS Multiple mechanisms contribute to reduced pelvic floor function in patients with PCOS, including hormonal imbalances, metabolic disturbances, inflammatory responses, and biomechanical alterations (71)

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Note: Results may vary based on age, lifestyle, and skin type