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In the obese trial cohort, 1 mg moved 24-hour heart rate by +0.7 bpm in the first week, essentially placebo. In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6. Lean, younger participants had more reactive heart-rate control than the sedentary, obese, and metabolically stressed trial population

[DOI] [PubMed] [Google Scholar] 44.Siraj MA, et al

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Targeting 0.7 to 1 gram of protein per pound of body weight provides a reasonable goal for most patients

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Dysbiosis impairs incretin signaling, reducing the effectiveness of GLP-1 therapies