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However, emerging evidence suggests a potential link between GLP-1 therapy and altered pain perception, possibly through several mechanisms: 1- Neuroinflammation and Microglial Activation: GLP-1 receptors are expressed in the brainstem, spinal cord, and dorsal root ganglia, regions involved in pain modulation

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This shift is connected to the body metabolizing more fat, but it may be important in terms of safety, particularly for individuals with comorbidities