& Thorburn, A
(2021) demonstrated how AI systems can modulate therapy in response to fluctuating inflammation levels [236]
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53 It is important to note that the virus can cause both an increase in oxidative stress (and therefore inflammation), as well as mitochondrial dysfunction which can lead to a loss of proteostasis and increase in endoplasmic reticulum stress
To summarize, mitophagy is crucial in the management of DKD, and an imbalance of mitophagy can lead to an increase in apoptosis, cellular iron death, accelerated cellular senescence, ROS production, as has the intensity of inflammatory responses, activation of the NLRP3 inflammatory vesicles, an augmentation in oxidative stress, and a decrease in mitochondrial biogenesis, but these can be solved through drugs or compounds such as TSF, JCYSTL, and metformin (Figs
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