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Pegylated arginine arginase (PEG-BCT-100) showed promising tumor suppressive activity, survival advantage, and safety against advanced HCC in phase I clinical trials of combination chemotherapy (oxaliplatin and capecitabine)

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doi: 10.1016/S2213-8587(24)00087-1 93 KhnenPWabitschMvon SchnurbeinJChirilaCMallyaUGCallahanPet al

The most robust evidence to date comes from a phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), in which retatrutide was evaluated over 48 weeks in adults with obesity but without type 2 diabetes