Both responses correlated with GSH redox changes, with diamide increasing GSSG, and hydrogen peroxide inducing protein-GSH mixed disulfides (GSSR)
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A post-mortem study of human pancreases demonstrated proliferative effects in those cases with GLP-1RA use, which were manifest by an increased mass of the pancreas along with increased frequency of PanIN1 and PanIN2 lesions compared to diabetes controls 23
This also indicates a role of APLN/APLNR signaling in the regulation of immunological processes, which needs to be further investigated
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