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Native GLP-1 has a half-life measured in minutes because it is cleaved rapidly by dipeptidyl peptidase IV

While a price reduction would help many more patients access the drug, it could have an additional benefit of making the drugs a less attractive target for counterfeiters

While there are varying perspectives on this issue, in a viewpoint that I was pleased to co-author with Sam Klein and Kevin Hall just published in JAMA, we suggest that the concern regarding physical frailty or sarcopenia with GLP-1-based medications may not be as grounded as some argue

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Choi J, Singh AK, Chen X, Lv JR, Kim WK

Others may be close to menopause or have already gone through it