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Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, et al

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This study was performed to develop an oral chimeric GLP-1A that can utilize ASBT-mediated endocytosis through conjugation with oligomeric bile acids (Scheme 1)

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Two estimands (treatment regimen estimand and efficacy estimand), based on the ICH E9(R1) guidance 32 , were used to assess treatment efficacy from different perspectives and accounted for intercurrent events differently

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