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Competing interest The authors declare no competing interests

Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin

These systems metabolize and scavenge for reactive oxygen species in a controlled and precise fashion

No interruptions

When glutathione levels are adequate, this process runs efficiently in the background

Although the exact mechanism behind this synergy remains unclear, it may involve destabilization of the bacterial outer membrane through the depolymerase action 135