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Complicating matters, signaling downstream of GHSR1a involves amplification of agouti-related peptide (AgRP), which is an inverse agonist of MC3R (Breit et al., 2006

They act as benzodiazepine agonists in the brain, reducing anxiety (15)

These studies span dose ranges that encompass probable human exposures

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Most people find that starting with 200-400 mcg per day is a good range, but its always best to get advice from a healthcare professional based on your specific needs

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