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The active forms of vitamin B12, methylcobalamin or 5-adenosyl-5-cobalamin, can each enter their respective biochemical cycles in the human body without prior change when administered to patients with vitamin B12 deficiency if they reach the tissues

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Besides their role in inflammation, these cytokines are detrimental to the processes of fertilization and embryo development: TNF- increases the free implants adhesions and their invasiveness through its effect on matrix metallo-proteinases (157) while TGF- hinders the local immune activity by inhibiting the natural killer cells which in turn impede the development of embryos (158)

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Mesenteries and intestines were embedded in OCT (Leica Biosystems, #14020108926) and kept at 80 C until sectioning

This allows for quick sensitivity analysis of different scenarios