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7 Over 55% of the weighting in this meta-analysis was contributed by the LOOK AHEAD trial, which assessed whether intensive lifestyle interventions for weight loss would reduce cardiovascular morbidity and mortality in individuals with overweight or obesity and type 2 diabetes (T2DM)

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The before-and-after differences can be truly remarkable

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Study limitations Oral NAC is associated with gastrointestinal discomfort, nausea, and diarrhea, but these symptoms are generally mild and occur at similar rates in placebo groups, indicating that NAC is well-tolerated and safe for chronic use [108]

Mild side effects may include temporary fatigue or flushing