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Some of the earlier GLP-1 compounds appear to access the brain more readily than semaglutide, Kanoski says

amitriptyline, clomipramine), MAO inhibitors (phenelzine, tranylcypromine, selegiline), as well as certain analgesics and other agents with serotonergic activity (for example, meperidine, tramadol, fentanyl, dextromethorphan, and the antibiotic linezolid)

Wegovy carries the same list price as Saxenda at $1,349 per month, but Novo Nordisk introduced a standard self-pay price of $349 per month in November 2025, with a limited-time introductory price of $199 per month for new self-pay patients on the two lowest doses