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Is helpful in relieving or preventing fatigue and may have action in the anti-inflammatory process by reducing histamine release

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Of note, almost half of patients treated with GLP-1-RAs also had pre-existing migraine as comorbidity (26.7% in the UCWM group), which could predispose them to worse (rather than better) headache outcomes [31], providing additional evidence of a favorable effect of GLP-1-RAs on headache improvement

Increasing water, fiber, and physical activity, and spacing doses optimally, usually resolve constipation within 2 to 4 weeks

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While these observations remain context-dependent and model-specific, they contribute to ongoing research interest in multi-receptor peptide systems