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And the reward system is a mechanism in the brain that makes us happy when we enjoy things, when we enjoy red wine and food and things like that

This gradual titration helps minimise adverse effects and improve tolerability

The researchers noted, however, that some users reported previously unrecognized potential side effects

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Appetite suppression continues at the same level, but metabolic rate has adjusted to the new body weight, and caloric expenditure matches the reduced intake

Acta Psychiatr Scand 139:404419 Konsman J, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications