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Research models with baseline HbA1c above 6.0% or fasting glucose above 110 mg/dL should not initiate this protocol without continuous glucose monitoring, as MK-677 specifically has been shown to increase fasting glucose by 58 mg/dL and HbA1c by 0.30.5% even in metabolically healthy subjects

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Yesespecially GLP-1 peptides, which regulate appetite and metabolism

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Most importantly, tirzepatide appears to restore the bodys hormonal signaling system rather than bypassing it like TRT does