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doi: 10.1038/icb.1943.20

in vitro experiments demonstrated that SGK1 knockdown attenuated erastin-induced downregulation of Slc7a11, GPX4, GSH, and oxidized glutathione (GSSG), while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting SGK1's critical role in CHD-associated ferroptosis (44)

10.1016/j.tox.2021.153027 30 ElbarbryF.AbdelkawyK.MoshirianN.Abdel-MegiedA

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NAD + deficiency can also be endogenous, a secondary consequence of metabolic disease