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In our CRISPR screens, we successfully identified known heavy metal transporters, including the metal importer SLC39A14, which mediates the uptake of cadmium in addition to manganese, iron, and zinc (Girijashanker et al, 2008), and the multidrug resistance protein MRP1/ABCC1, responsible for the export of mercuryglutathione and arsenicglutathione conjugates (Leslie et al, 2004

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Understanding Glutathione: The Master Antioxidant What is Glutathione Glutathione is a natural tripeptide antioxidant composed of three amino acids: glutamic acid, cysteine, and glycine

Additionally, certain genetic variations can make it more difficult for some individuals to produce and maintain optimal levels of glutathione

doi:10.1002/hep.1840090324

Clinical Applications: