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Every third residue in the collagen triple helix is a glycine molecule, highlighting glycines importance in maintaining the tensile strength and integrity of skin, bones, cartilage, and tendons

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

This stall is a known physiological response to prolonged caloric restriction

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Clin Exp Rheumatol (2020) 38(4):71323

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