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Loomba R, Hartman M L, Lawitz E J, et al

New mitochondrial-targeted drugs, such as mtDNA repair agents and mitochondrial membrane stabilizers, along with metabolic modulators (e.g., PDK inhibitors, FASN inhibitors), epigenetic modifiers (e.g., DNA methyltransferase inhibitors (DNMTi), lysine methyltransferase inhibitors (KMTi)), and signaling pathway modulators (e.g., AKT inhibitors, STAT3 inhibitors), are key areas for future development

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Pediatr Neurol, 2005