henry tirzepatide med finally said something... : r/tirzepatidecompound Henry Meds Weight Loss Review

A study involving 330 patients with Child-Turcotte-Pugh class B/C cirrhosis and high-risk esophageal varices showed that the 1-year first bleeding rate in the group treated with carvedilol (a non-selective -AR antagonist with 1-AR antagonistic activity) combined with variceal band ligation was significantly lower (6.3%) than that in the carvedilol monotherapy group (20%) and the variceal band ligation monotherapy group (14.5%)

[DOI] [PubMed] [Google Scholar] 67.Baskin DG

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and (iv) Rolling Review, which means that a drug company can submit completed sections of its BLA or NDA for review by the FDA, rather than waiting until every section of the NDA or BLA is completed before the entire application can be reviewed

A small observational study (2023) in the journal *Obesity* suggested additive weight loss in a cohort of 47 patients on both agents, but sample size, lack of randomization, and absence of long-term follow-up prevent firm conclusions

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